Sildenafil is a potent phosphodiesterase-5 (PDE-5) inhibitor extensively studied in preclinical and in-vitro models examining cyclic guanosine monophosphate (cGMP) signaling pathways. This 100 mg tablet formulation is designed for comprehensive laboratory research applications investigating PDE-5 enzyme function, downstream signaling cascades, and smooth muscle physiology. Available as pharmaceutical-grade tablets for controlled experimental settings in vascular and smooth muscle research.

Chemical Specifications:

• Chemical Name: 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine
• Molecular Formula: C22H30N6O4S
• Molecular Weight: 474.58 g/mol
• Compound Class: Phosphodiesterase-5 inhibitor

Sildenafil functions as a selective inhibitor of PDE-5, which regulates cGMP hydrolysis in smooth muscle cells. Research models employ sildenafil to investigate vascular signaling, enzyme kinetics, and cGMP-dependent pathways relevant to vascular biology and endothelial function studies.

Research Applications:

• Examining phosphodiesterase-5 enzyme inhibition kinetics in cell-free assays
• Modeling cGMP signaling in vascular smooth muscle cell cultures
• Investigating PDE-5-mediated pathways in vascular endothelial tissue preparations
• Characterizing compound potency and selectivity in enzyme assays
• Evaluating dose-response relationships in preclinical smooth muscle models

Storage and Handling:

• Store at 2-8°C in light-resistant containers to maintain stability
• Keep in a cool, dry environment away from moisture exposure
• Maintain appropriate laboratory temperature controls during experimentation
• Handle with standard laboratory protocols for pharmaceutical-grade compounds

Product Specifications:

• Purity: >98% HPLC
• Form: Tablets, 100 mg each
• Appearance: White to off-white crystalline tablets
• Quantity: 100 tablets

FOR RESEARCH USE ONLY. Not intended for human consumption or clinical use. All products are sold strictly for laboratory, educational, and scientific research purposes.