Myostatin (GDF-8) is a TGF-β superfamily growth differentiation factor that functions as a negative regulator of skeletal muscle mass. Supplied as lyophilized powder, Myostatin is fundamental for research investigating myostatin signaling cascades, muscle atrophy pathways, and skeletal muscle development regulation in cellular and tissue models.

Chemical/Compound Information:

• Chemical Name: Growth Differentiation Factor 8 (GDF-8)
• Molecular Formula: C98H149N27O42
• Molecular Weight: 2375.36 g/mol
• Compound Class: TGF-β Superfamily Member

Myostatin functions as a secreted signaling protein activating ALK4/ActR2B heteromeric receptor complexes, triggering Smad2/3 phosphorylation and transcriptional repression of myogenic genes. Its study enables systematic investigation of negative myogenic regulation and muscle wasting mechanisms in preclinical models.

Research Applications:

• Myostatin receptor (ALK4/ActR2B) binding kinetics and heterodimerization studies
• Smad2/3 phosphorylation cascades and transcriptional target gene identification
• Myoblast differentiation inhibition and C2C12 myogenic marker suppression analysis
• Skeletal muscle atrophy pathway characterization in catabolic disease models
• Myostatin propeptide antagonism and growth factor neutralization efficacy assessment

Storage and Handling:

• Store at -20°C in sealed vial in light-protected, low-humidity environment
• Minimize freeze-thaw events; aliquot into single-use portions immediately upon receipt
• Reconstitute in sterile PBS or growth factor assay medium immediately before use
• Maintain inert (N2) headspace in vial between uses to prevent oxidation
• Use reconstituted solutions within 2 hours to preserve bioactivity

Product Specifications:

• Purity: ≥95% (HPLC/MS)
• Appearance: White to off-white lyophilized powder
• Form: Lyophilized powder
• Quantity: 1mg per vial

FOR RESEARCH USE ONLY. Not intended for human consumption or clinical use. All products are sold strictly for laboratory, educational, and scientific research purposes.