PT-141 (Bremelanotide) is a melanocortin receptor agonist with dual activity at MC3R and MC4R subtypes. Supplied as lyophilized powder, PT-141 serves as a valuable pharmacological tool for investigating neuropeptidergic signaling in hypothalamic neural circuits and melanocortin-dependent behavioral responses in preclinical neuroscience models.

Chemical/Compound Information:

• Chemical Name: PT-141 (Bremelanotide)
• Molecular Formula: C50H68N14O10
• Molecular Weight: 1025.15 g/mol
• Compound Class: Melanocortin Receptor Agonist (MC3R/MC4R selective)

PT-141 exhibits preferential activity at MC3R and MC4R relative to MC1R/MC5R, making it a useful tool for examining central melanocortin signaling. Its study enables investigation of neuropeptide Y pathway inhibition, propiomelanocortin (POMC) neuron activation, and behavioral effects of hypothalamic melanocortin signaling in mammalian models.

Research Applications:

• MC3R and MC4R receptor binding kinetics and subtype selectivity characterization
• POMC neuron activation and melanocortin pathway engagement in hypothalamic circuits
• Behavioral responses to melanocortin signaling in appetitive and homeostatic paradigms
• Comparative pharmacology: PT-141 vs. ACTH vs. α-MSH in MC receptor profiling
• Receptor internalization and desensitization kinetics in response to sustained exposure

Storage and Handling:

• Store at -20°C in sealed vial protected from light exposure
• Minimize freeze-thaw cycles; prepare single-use aliquots immediately upon receipt
• Reconstitute in sterile saline or PBS immediately before experimental application
• Maintain inert (N2) atmosphere in storage vials to prevent oxidative peptide degradation
• Use reconstituted solutions within 4 hours to preserve full neuropeptidergic activity

Product Specifications:

• Purity: ≥96% (HPLC/MS)
• Appearance: White to off-white lyophilized powder
• Form: Lyophilized powder
• Quantity: 10mg per vial

FOR RESEARCH USE ONLY. Not intended for human consumption or clinical use. All products are sold strictly for laboratory, educational, and scientific research purposes.