Larazotide Acetate is a synthetic peptide antagonist of zonulin, a regulatory protein governing intestinal epithelial tight junction permeability. Supplied as lyophilized powder, Larazotide is employed in research examining intestinal barrier function, tight junction protein dynamics, and paracellular transport modulation.

Chemical/Compound Information:

• Chemical Name: Larazotide Acetate (synthetic 9-residue peptide)
• Molecular Formula: C54H78N14O13
• Molecular Weight: 1159.28 g/mol
• Compound Class: Synthetic Peptide / Tight Junction Modulator

Larazotide represents a competitive inhibitor of zonulin-mediated claudin disassembly at tight junctions. Its use in preclinical models enables systematic investigation of paracellular permeability regulation and epithelial barrier integrity in intestinal tissue models.

Research Applications:

• Zonulin antagonism and tight junction stability assessment in intestinal epithelial monolayers
• Claudin-2 and occludin dynamics during barrier integrity studies
• Paracellular tracer permeability measurements in Caco-2 and primary enterocyte cultures
• Zonulin-induced permeability reversal kinetics and dose-response characterization
• Intestinal inflammation models and barrier recovery trajectories post-challenge

Storage and Handling:

• Store at -20°C in sealed vial protected from light exposure
• Minimize exposure to elevated temperature and humidity
• Reconstitute in sterile PBS or appropriate cell culture medium
• Aliquot into single-use portions to prevent repeated freeze-thaw degradation

Product Specifications:

• Purity: ≥95% (HPLC/MS)
• Appearance: White to off-white lyophilized powder
• Form: Lyophilized powder
• Quantity: 5mg per vial

FOR RESEARCH USE ONLY. Not intended for human consumption or clinical use. All products are sold strictly for laboratory, educational, and scientific research purposes.