MOTS-C (Mitochondrial-Derived Peptide) is an endogenous 16-amino acid peptide originating from the mitochondrial genome. Supplied as lyophilized powder, MOTS-C is essential for investigating mitochondrial signaling autonomy, AMPK pathway activation, and mitochondrial-nuclear crosstalk in cellular bioenergetics research.

Chemical/Compound Information:
• Chemical Name: MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA-C)
• Molecular Formula: C69H108N18O17
• Molecular Weight: 1457.71 g/mol
• Compound Class: Mitochondrial-Derived Signaling Peptide

MOTS-C represents a unique signaling molecule produced by mitochondrial DNA, challenging classical concepts of mitochondrial function as purely energetic. Its investigation enables examination of mitochondrial-to-nucleus signaling, metabolic adaptation responses, and AMPK-dependent cellular stress management in preclinical models.

Research Applications:
• AMPK pathway activation and downstream substrate phosphorylation kinetics
• Mitochondrial bioenergetics optimization and oxygen consumption rate analysis
• Cellular glucose utilization patterns and metabolic switching in response to MOTS-C
• SIRT1/NAD+-dependent deacetylation of metabolic enzymes
• Mitochondrial-nuclear gene expression coordination during metabolic adaptation

Storage and Handling:
• Store at -20°C in sealed vial protected from light exposure
• Minimize freeze-thaw cycles; prepare single-use aliquots immediately
• Reconstitute in sterile PBS or appropriate cell culture medium
• Maintain inert atmosphere (N2) headspace for storage beyond 3 months
• Use within 4 hours of reconstitution to preserve bioactivity

Product Specifications:
• Purity: ≥96% (HPLC/MS)
• Appearance: White to off-white lyophilized powder
• Form: Lyophilized powder
• Quantity: 10mg per vial

FOR RESEARCH USE ONLY. Not intended for human consumption or clinical use. All products are sold strictly for laboratory, educational, and scientific research purposes.