Minoxidil is a potassium channel (KATP) opener with selective vascular activity. Supplied as lyophilized powder, Minoxidil serves as a fundamental research compound for investigating ion channel pharmacology, vascular tissue responses, and cellular signaling mechanisms downstream of KATP channel activation in diverse tissue models.

Chemical/Compound Information:

• Chemical Name: 6-(Piperidin-1-yl)pyrimidine-2,4-diamine
• Molecular Formula: C9H15N5O
• Molecular Weight: 209.24 g/mol
• Compound Class: KATP Channel Opener / Vasodilator

Minoxidil activates KATP channels by opening the inward rectifier K+ conductance, leading to hyperpolarization and smooth muscle relaxation. This mechanism permits systematic investigation of potassium channel physiology, ion channel regulation, and hyperpolarization-dependent cellular responses in vascular and other tissues.

Research Applications:

• KATP channel selectivity and activation kinetics in isolated patch-clamp recordings
• Vascular smooth muscle hyperpolarization and vasodilation dose-response characterization
• Ion channel modulation by cellular signaling cascades (PKA, PKC pathways)
• Comparative KATP opener efficacy screening in vascular tissue preparations
• Cellular energy sensing and AMPK-KATP crosstalk investigation

Storage and Handling:

• Store lyophilized powder at 2-8°C in sealed vial with desiccant
• Protect from light exposure; use light-protected storage containers
• Reconstitute in appropriate assay buffer or sterile water immediately before use
• Minimize freeze-thaw cycles; aliquot into single-use portions
• Prepare working solutions fresh for optimal channel activation

Product Specifications:

• Purity: ≥98% (HPLC)
• Appearance: White to off-white lyophilized powder
• Form: Lyophilized powder
• Quantity: 5mg per vial

FOR RESEARCH USE ONLY. Not intended for human consumption or clinical use. All products are sold strictly for laboratory, educational, and scientific research purposes.