Sermorelin Acetate is a synthetic 29-amino acid GHRH analog (GRF 1-29) functioning as a growth hormone-releasing hormone receptor agonist. Supplied as lyophilized powder, Sermorelin is essential for investigating GHRH receptor pharmacology, somatotropin secretion stimulation, and growth hormone axis signaling in endocrine and neuroendocrine research models.

Chemical/Compound Information:

• Chemical Name: Sermorelin Acetate (Growth Hormone Releasing Factor 1-29)
• Molecular Formula: C149H246N44O42
• Molecular Weight: 3357.89 g/mol
• Compound Class: GHRH Receptor Agonist / Peptide Hormone

Sermorelin exhibits full agonist activity at GHRH receptors, stimulating somatotroph GH secretion through cAMP-dependent signaling. Its investigation permits systematic examination of GH axis regulation, somatotropin release kinetics, and GHRH receptor-mediated endocrine responses in pituitary tissue models.

Research Applications:

• GHRH receptor (GHRHR) binding kinetics and ligand-receptor interaction characterization
• GH secretion stimulation and somatotroph cAMP production in pituitary tissue preparations
• GH pulse frequency and amplitude modulation via GHRH signaling optimization
• Receptor desensitization and homologous regulation of GHRHR in prolonged exposure studies
• Comparative GHRH agonist efficacy: native GHRH vs. sermorelin in receptor assays

Storage and Handling:

• Store at -20°C in sealed vial protected from light and moisture
• Minimize freeze-thaw cycles; prepare single-use aliquots immediately
• Reconstitute in sterile PBS or appropriate assay buffer immediately before use
• Maintain inert (N2) atmosphere in storage vials to prevent peptide oxidation
• Use within 4 hours of reconstitution to preserve endocrine bioactivity

Product Specifications:

• Purity: ≥95% (HPLC/MS)
• Appearance: White to off-white lyophilized powder
• Form: Lyophilized powder
• Quantity: 5mg per vial

FOR RESEARCH USE ONLY. Not intended for human consumption or clinical use. All products are sold strictly for laboratory, educational, and scientific research purposes.