Melanotan 1 Acetate, also designated as Afamelanotide, is a selective melanocortin-1 (MC1R) receptor agonist. Supplied as lyophilized powder, MT-1 is instrumental in preclinical research examining MC1R pharmacology, melanocortin signaling specificity, and ligand-receptor interaction kinetics in cellular and tissue models.

Chemical/Compound Information:

• Chemical Name: Melanotan I acetate salt (Afamelanotide)
• Molecular Formula: C78H111N21O18
• Molecular Weight: 1649.82 g/mol
• Compound Class: MC1R-Selective Agonist

MT-1 exhibits high selectivity for melanocortin-1 receptors relative to other MC receptor subtypes, making it a preferred tool for isolating MC1R-specific signaling outcomes. Its use enables delineation of MC1R-dependent mechanisms from pleiotropic effects of non-selective melanocortin agonists.

Research Applications:

• MC1R receptor selectivity profiling and ligand-binding kinetics characterization
• Melanocytic signaling pathway investigation in primary melanocyte cultures
• Comparative pharmacology: MT-1 vs. ACTH or non-selective melanocortin agonists
• cAMP generation and GPCR downstream signaling cascade analysis
• Structure-activity relationship (SAR) studies using MC1R-selective reference compounds

Storage and Handling:

• Store at -20°C in sealed vial in light-protected environment
• Maintain low humidity; include desiccant pack in storage container
• Reconstitute in sterile saline or assay-appropriate buffer
• Minimize exposure to freeze-thaw cycles; prepare aliquots for single use
• Use within 4 hours of reconstitution for optimal activity

Product Specifications:

• Purity: ≥96% (HPLC/MS)
• Appearance: White to off-white lyophilized powder
• Form: Lyophilized powder
• Quantity: 10mg per vial

FOR RESEARCH USE ONLY. Not intended for human consumption or clinical use. All products are sold strictly for laboratory, educational, and scientific research purposes.