Mechano Growth Factor (MGF) is an IGF-1 splice variant (IGF-1Ec) specifically induced by mechanical loading and muscle damage. Supplied as lyophilized powder, MGF represents a critical research tool for investigating mechanical stress responses, muscle adaptation signaling, and growth factor-mediated tissue repair in skeletal muscle models.

Chemical/Compound Information:

• Chemical Name: Mechano Growth Factor (IGF-1Ec)
• Molecular Formula: C174H264N50O56S
• Molecular Weight: 4010.52 g/mol
• Compound Class: IGF-1 Splice Variant / Growth Factor

MGF differs from systemic IGF-1 through alternative splicing, creating a unique E-domain peptide extension. This structural distinction enables selective investigation of mechanical stress-responsive growth signaling independent of endocrine IGF-1 effects, making it essential for mechanobiology research.

Research Applications:

• Mechanical load-induced gene expression profiling in myogenic cell cultures and tissue explants
• Muscle damage and regeneration signaling cascade investigation
• IGF-1 receptor (IGF-1R) activation kinetics comparing MGF vs. systemic IGF-1
• Myoblast proliferation and differentiation responses to mechanical stress-mimic stimuli
• Extracellular matrix remodeling and satellite cell mobilization in skeletal muscle models

Storage and Handling:

• Store at -20°C in sealed vial protected from light and moisture
• Minimize freeze-thaw cycles; prepare single-use aliquots
• Reconstitute in sterile saline or growth factor assay medium
• Maintain inert atmosphere headspace for extended storage
• Use within 2 hours of reconstitution for optimal bioactivity

Product Specifications:

• Purity: ≥95% (HPLC/MS)
• Appearance: White to off-white lyophilized powder
• Form: Lyophilized powder
• Quantity: As specified per vial labeling

FOR RESEARCH USE ONLY. Not intended for human consumption or clinical use. All products are sold strictly for laboratory, educational, and scientific research purposes.