PEG-MGF (PEGylated Mechano Growth Factor) is a modified form of the IGF-1Ec splice variant with polyethylene glycol conjugation. Supplied as lyophilized powder, PEG-MGF is instrumental for investigating extended half-life growth factor analogs, pharmacokinetic properties of PEGylated peptides, and long-acting mechanisms in preclinical muscle research.

Chemical/Compound Information:

• Chemical Name: PEGylated Mechano Growth Factor (IGF-1Ec variant)
• Molecular Formula: C~350H~550N~60O~130 (approximate)
• Molecular Weight: ~8000-10000 g/mol (estimated)
• Compound Class: PEGylated IGF-1 Splice Variant

PEG conjugation significantly extends peptide half-life by reducing proteolytic degradation and enhancing plasma retention. This modification enables investigation of sustained growth factor signaling and comparison of acute vs. sustained IGF-1R activation outcomes in skeletal muscle adaptation models.

Research Applications:

• Pharmacokinetic modeling and sustained IGF-1R signaling duration characterization
• PEGylation effects on growth factor bioavailability and tissue distribution
• Muscle protein synthesis induction via sustained vs. acute IGF-1Ec exposure
• In-vivo muscle adaptation responses to extended-duration growth factor treatment
• Comparative efficacy: PEG-MGF vs. native MGF in equivalent molar dosing studies

Storage and Handling:

• Store at -20°C in sealed vial protected from light exposure
• Minimize freeze-thaw events; prepare single-use aliquots for each experiment
• Reconstitute in sterile saline or growth factor medium immediately before use
• Maintain inert (N2) headspace to prevent polymer oxidation and peptide degradation
• Use within 6 hours of reconstitution to preserve PEGylated peptide stability

Product Specifications:

• Purity: ≥94% (HPLC/MS)
• Appearance: White to off-white lyophilized powder
• Form: Lyophilized powder
• Quantity: As specified per vial labeling

FOR RESEARCH USE ONLY. Not intended for human consumption or clinical use. All products are sold strictly for laboratory, educational, and scientific research purposes.