MK-677 (Ibutamoren) is a non-peptide selective agonist of the ghrelin receptor (GHSR). Supplied as compressed tablets, MK-677 facilitates preclinical research into growth hormone secretagogue receptor signaling, ghrelin-mimetic pathways, and GH axis regulation in cellular and animal model systems.

Chemical/Compound Information:

• Chemical Name: (1R)-1-[2-Oxa-5-azabicyclo[3.3.0]oct-6-yl]-N-(2-propylpentanoyl)methanamine
• Molecular Formula: C27H36N4O4S
• Molecular Weight: 528.67 g/mol
• Compound Class: Ghrelin Receptor Agonist (Non-peptide)

MK-677 represents a non-peptide alternative to peptide GH secretagogues, exhibiting high oral bioavailability and selectivity for GHSR. Its application in research enables oral delivery pharmacology studies and investigation of ghrelin signaling independent of peptide degradation limitations in preclinical models.

Research Applications:

• GHSR agonism and ghrelin mimetic pharmacology in cell-based assays
• Growth hormone secretion stimulation and GH pulse frequency/amplitude analysis
• Appetite signaling and hypothalamic neuropeptide Y activation in animal models
• GHSR expression profiling and receptor density assessment in tissue preparations
• Comparative GH secretagogue efficacy: peptide vs. non-peptide agonist screening

Storage and Handling:

• Store compressed tablets at room temperature (20-25°C) in sealed, light-protected bottle
• Maintain low-humidity environment; keep desiccant in original container
• Protect from direct sunlight and moisture exposure
• Verify seal integrity before use; discontinue if compromised
• Store in original packaging to maintain tablet integrity

Product Specifications:

• Purity: ≥99% (HPLC)
• Appearance: White to off-white compressed tablets
• Form: Compressed tablets
• Quantity: 100 tablets (10mg each)

FOR RESEARCH USE ONLY. Not intended for human consumption or clinical use. All products are sold strictly for laboratory, educational, and scientific research purposes.